sma4dSMAD4 is the only common SMAD in TGF-β snaling that usually impedes immune cell activation in the tumor microenvironment. However, we demonstrated here thatBioGRID Interaction 297491 Between SEMA4D And PTPRC. sema domain, immunoglobulin domain (), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D